In a post on Instagram with a family photo, she said she was “completely devastated” and that there were not “enough words to describe our pain”.
The couple had four daughters including Gianna, 13, who died in the crash.
There has been no word yet on funeral arrangements.
The cause of the crash in foggy weather west of Los Angeles is still being investigated. Bryant was on his way to coach his daughter’s basketball team in a local youth tournament at the Mamba Sports Academy.
In her post, Vanessa also said: “We are completely devastated by the sudden loss of my adoring husband, Kobe – the amazing father of our children; and my beautiful, sweet Gianna – a loving, thoughtful, and wonderful daughter, and amazing sister to Natalia, Bianka, and Capri.”
She added: “I wish they were here with us forever. They were our beautiful blessings taken from us too soon. I’m not sure what our lives hold beyond today, and it’s impossible to imagine life without them.”
The other people who died in the crash were Ara Zobayan, 49, the pilot; Christina Mauser, 38, an assistant basketball coach at Bryant’s Mamba Sports Academy; John Altobelli, 56, the head baseball coach at Orange Coast College in Costa Mesa, California; his wife, Keri Altobelli, 46; their daughter Alyssa Altobelli, 13; Payton Chester, 13, who played on the academy’s basketball teams; and her mother, Sarah Chester, 45.